1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

Base Information

Chemical Name:1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide
CAS No.:1325762-66-0
Molecular Formula:C₁₉H₁₉F₃N₂O₃
Molecular Weight:380.367
Hs Code.:

Synonyms:1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

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Chemical Property of 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

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Technology Process of 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

There total 6 articles about 1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₇F₃N₂O₅

: 1325762-66-0
1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

Guidance literature:: C₂₄H₂₇F₃N₂O₅; With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 1h;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 127271-65-2
1-fluoro-4-methoxy-2-(trifluromethyl)benzene

: 1325762-66-0
1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

1.2: 2.5 h / 20 - 100 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

3.1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C

4.1: hydrogen; ammonia / Raney nickel / methanol / 3 h / 20 °C / 2585.81 Torr

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 2 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

With ammonia; hydrogen; sodium hydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1-benzyloxy-4-methoxy-2-trifluoromethyl-benzene

: 1325762-66-0
1-amino-cyclopropanecarboxylic acid 4-(4-methoxy-2-trifluoromethyl-phenoxy)-benzylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 4 h / 20 °C / 2585.81 Torr

2.1: potassium carbonate / dimethyl sulfoxide / 3 h / 120 °C

3.1: hydrogen; ammonia / Raney nickel / methanol / 3 h / 20 °C / 2585.81 Torr

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 2 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane; water / 1 h / 20 °C

With ammonia; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;