(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Base Information

Chemical Name:(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene
CAS No.:1443743-99-4
Molecular Formula:C₂₉H₂₀F₃NO
Molecular Weight:455.479
Hs Code.:

Synonyms:(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Suppliers and Price of (E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

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Technology Process of (E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

There total 6 articles about (E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1443743-98-3
(E)-1-bromo-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

: 126747-14-6
4-cyanophenylboronic acid

: 1443743-99-4
(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate; In water; toluene; at 20 - 90 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ol401333j

Reference yield:

: 1443743-97-2
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

: 1443743-99-4
(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; sodium methylate / dichloromethane; methanol / 2.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate / toluene; water / 12 h / 20 - 90 °C / Inert atmosphere; Schlenk technique

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; bromine; sodium methylate; potassium carbonate; In methanol; dichloromethane; water; toluene;
DOI:10.1021/ol401333j

Reference yield:

: 1443743-83-6
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-methoxyphenyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethene

: 1443743-99-4
(E)-1-(4-cyanophenyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; water / 12 h / Inert atmosphere; Schlenk technique; Reflux

2: bromine; sodium methylate / dichloromethane; methanol / 2.08 h / -78 - 20 °C / Inert atmosphere; Schlenk technique

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; potassium carbonate / toluene; water / 12 h / 20 - 90 °C / Inert atmosphere; Schlenk technique

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-tert-butyl phosphine; tetrabutylammomium bromide; bromine; sodium methylate; potassium carbonate; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol401333j