(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Base Information

Chemical Name:(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene
CAS No.:1443743-97-2
Molecular Formula:C₃₀H₂₇F₃OSi
Molecular Weight:488.624
Hs Code.:

Synonyms:(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

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Technology Process of (Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

There total 4 articles about (Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 455-13-0
4-Iodobenzotrifluoride

: 1443743-83-6
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-methoxyphenyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethene

: 1443743-97-2
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; potassium hydroxide; In tetrahydrofuran; water; for 12h; Inert atmosphere; Schlenk technique; Reflux;
DOI:10.1021/ol401333j

Reference yield:

: 185990-03-8
dimethylphenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)silane

: 1443743-97-2
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 1,1,3,3-tetramethylbutane isonitrile / toluene / 2 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide / tetrahydrofuran; water / 12 h / 20 °C / Schlenk technique; Inert atmosphere

3: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; water / 12 h / Inert atmosphere; Schlenk technique; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; 1,1,3,3-tetramethylbutane isonitrile; palladium diacetate; potassium hydroxide; In tetrahydrofuran; water; toluene; 2: |Suzuki-Miyaura Coupling / 3: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol401333j

Reference yield:

: 3839-31-4
dimethyl(phenyl)silyl lithium

: 1443743-97-2
(Z)-1-(dimethylphenylsilyl)-1-phenyl-2-(4-trifluoromethylphenyl)-2-(4-methoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 4 steps

1: Inert atmosphere; Schlenk technique

2: palladium diacetate; 1,1,3,3-tetramethylbutane isonitrile / toluene / 2 h / 20 °C / Inert atmosphere; Schlenk technique; Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium hydroxide / tetrahydrofuran; water / 12 h / 20 °C / Schlenk technique; Inert atmosphere

4: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / tetrahydrofuran; water / 12 h / Inert atmosphere; Schlenk technique; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; 1,1,3,3-tetramethylbutane isonitrile; palladium diacetate; potassium hydroxide; In tetrahydrofuran; water; toluene; 3: |Suzuki-Miyaura Coupling / 4: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol401333j