N-phenylisobutyrimidamide

Base Information

• Chemical Name: N-phenylisobutyrimidamide
• CAS No.: 25844-23-9
• Molecular Formula: C₁₀H₁₄N₂
• Molecular Weight: 162.235
• Mol file: 25844-23-9.mol

Synonyms:N-phenylisobutyrimidamide

Chemical Property of N-phenylisobutyrimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenylisobutyrimidamide

There total 5 articles about N-phenylisobutyrimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1,2-Diiodobenzene (615-42-9) + isobutyramidine (57536-10-4) → N-phenylisobutyramidine (25844-23-9) + 2-isopropylbenzimidazole (5851-43-4)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In 1-methyl-pyrrolidin-2-one; at 170 ℃; Inert atmosphere;

DOI:10.1021/jo900912h

Reference yield: 50.0%

2-methylpropanimidamide hydrochloride (22007-68-7) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → N-phenylisobutyrimidamide (25844-23-9)

Guidance literature:

With caesium carbonate; cesium fluoride; In acetonitrile; at 50 ℃; for 5h;

DOI:10.1016/j.tetlet.2015.06.017

Reference yield:

iodobenzene (591-50-4) + 2-methylpropanimidamide hydrochloride (22007-68-7) → N-phenylisobutyrimidamide (25844-23-9)

Guidance literature:

With copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.8b03383

upstream raw materials:

ISOPROPYLAMIDE

aniline

2-methylpropanimidamide hydrochloride

2-(trimethylsilyl)phenyl trifluoromethanesulfonate

Downstream raw materials:

N-phenyl-isobutyrimidoyl chloride

4,5‐dimethyl‐2‐phenyl‐1H-benzoimidazole

Refernces

• 1、 Coles,Mahon,Webster. "1,1-Diphosphines and divinylphosphines via base catalyzed hydrophosphination". supporting information. p. 10443 - 10446. Retrieved 2018/09/21.
• 2、 Deng, Xiaohu,McAllister, Heather,Mani, Neelakandha S.. "CuI-catalyzed amination of arylhalides with guanidines or amidines: A facile synthesis of 1-H-2-substituted benzimidazoles". supporting information; experimental part. p. 5742 - 5745. Retrieved 2009/12/06.