5851-43-4 Usage
General Description
2-Isopropylbenzimidazole is a chemical compound categorized under organic substances, particularly aromatic homomonocyclic compounds. It is characterized by a benzimidazole core structure, which is a bicyclic compound having nitrogen atoms at positions 1 and 3. The benzimidazole ring is substituted with an isopropyl group in this specific compound. Little is known about its specific uses or properties; however, benzimidazoles in general are commonly utilized in pharmaceuticals, including antifungal and anthelmintic medicines. The presence of the isopropyl group could potentially modify the properties of the benzimidazole ring, potentially altering its binding affinity or bioavailability in specific applications.
Check Digit Verification of cas no
The CAS Registry Mumber 5851-43-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,8,5 and 1 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 5851-43:
(6*5)+(5*8)+(4*5)+(3*1)+(2*4)+(1*3)=104
104 % 10 = 4
So 5851-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2/c1-7(2)10-11-8-5-3-4-6-9(8)12-10/h3-7H,1-2H3,(H,11,12)
5851-43-4Relevant articles and documents
I2/TBHP promoted oxidative C–N bond formation at room temperature: Divergent access of 2-substituted benzimidazoles involving ring distortion
Saha, Moumita,Das, Asish R.
supporting information, p. 2520 - 2525 (2018/05/31)
A new ‘one pot’ tandem synthesis of 2-substituted benzimidazoles has been developed from 2-aminobenzyl alcohol/2-aminobenzamide and different coupling partners (nitriles, aldehydes and 1,3-diketones) via iodine and TBHP promoted oxidative ring contraction. The present strategy involves sequential C–N bond formation, cyclization, subsequent ring contraction and dehydrogenation to afford various medicinally important benzimidazole derivatives in moderate to good yields. This operationally simple synthetic approach proceeds at room temperature under base-free condition, broadly applicable to a wide array of nitriles and aldehydes bearing oxidation prone functional groups and noteworthy to mention that various acyclic 1,3-diketones undergo selective C–C bond cleavage leading to 2-alkyl benzimidazoles under mild condition.
