1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline

Base Information

• Chemical Name: 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzo
• Molecular Formula: C₃₁H₂₇NO₄S₂
• Molecular Weight: 541.692

Synonyms:1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline

Chemical Property of 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzo

Chemical Property:

Purity/Quality:

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Useful:

There total 4 articles about 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3,4-dihydroisoquinoline (3230-65-7) + 1,3-bis(phenylsulfonyl)-4-phenyl-1,3-butadiene (96540-11-3) → 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline (133167-31-4)

Guidance literature:

In dichloromethane; at 50 ℃; for 24h;

DOI:10.1021/jo00008a026

Reference yield:

(3-bromo-propenyl)-phenyl sulfone (36199-65-2) → 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline (133167-31-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / methanol / 0.58 h / Heating

2: 81 percent / piperidine, glacial acetic acid / benzene / 4 h / Heating

3: 93 percent / CH₂Cl₂ / 24 h / 50 °C

With piperidine; acetic acid; In methanol; dichloromethane; benzene;

DOI:10.1021/jo00008a026

Reference yield:

1,3-bis(phenylsulfonyl)-1-propene (38513-20-1) → 1,3-bis(phenylsulfonyl)-4-phenyl-3,4,6,7-tetrahydro-11bH-benzoquinoline (133167-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / piperidine, glacial acetic acid / benzene / 4 h / Heating

2: 93 percent / CH₂Cl₂ / 24 h / 50 °C

With piperidine; acetic acid; In dichloromethane; benzene;

DOI:10.1021/jo00008a026

upstream raw materials:

3,4-dihydroisoquinoline

1,3-bis(phenylsulfonyl)-4-phenyl-1,3-butadiene

(3-bromo-propenyl)-phenyl sulfone

1,3-bis(phenylsulfonyl)-1-propene

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