2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

Base Information

Chemical Name:2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one
CAS No.:179998-89-1
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

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Chemical Property of 2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

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Technology Process of 2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

There total 7 articles about 2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 372-09-8
cyanoacetic acid

: 179998-88-0
2-(4-benzyloxybutyl)-4-hydroxymethyl-4-methylcyclohex-2-en-1-one

: 179998-89-1
2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

Guidance literature:: With pyridine; p-toluenesulfonyl chloride; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.1039/p19960001517

Reference yield:

: 24730-94-7
ethyl 1-methyl-2,4-dioxocyclohexane-1-carboxylate

: 179998-89-1
2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 30 percent / N-benzyltrimethylammonium hydroxide / methanol; H₂O / 36 h / Ambient temperature

2: 96 percent / pyridinium toluene-p-sulfonate / benzene / 12 h / Heating

3: 99 percent / H₂ / PtO₂ / ethyl acetate / 7 h / Ambient temperature

4: LiAlH₄ / diethyl ether / 2 h / Ambient temperature

5: 1 M aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature

6: 92 percent / toluene-p-sulfonyl chloride, pyridine / CH₂Cl₂ / 0.33 h / Ambient temperature

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; N-benzyl-trimethylammonium hydroxide; p-toluenesulfonyl chloride; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1039/p19960001517

Reference yield:

: 89358-30-5,105875-09-0,88088-58-8
(Z)-(((4-bromobut-2-en-1-yl)oxy)methyl)benzene

: 179998-89-1
2-(4-benzyloxybutyl)-4-(2-cyanoacetoxy)methyl-4-methylcyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 6 steps

1: 30 percent / N-benzyltrimethylammonium hydroxide / methanol; H₂O / 36 h / Ambient temperature

2: 96 percent / pyridinium toluene-p-sulfonate / benzene / 12 h / Heating

3: 99 percent / H₂ / PtO₂ / ethyl acetate / 7 h / Ambient temperature

4: LiAlH₄ / diethyl ether / 2 h / Ambient temperature

5: 1 M aq. HCl / tetrahydrofuran / 0.5 h / Ambient temperature

6: 92 percent / toluene-p-sulfonyl chloride, pyridine / CH₂Cl₂ / 0.33 h / Ambient temperature

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; hydrogen; pyridinium p-toluenesulfonate; N-benzyl-trimethylammonium hydroxide; p-toluenesulfonyl chloride; platinum(IV) oxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1039/p19960001517