5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine
CAS No.:1285534-91-9
Molecular Formula:C₄₃H₄₄N₆O₁₀
Molecular Weight:804.857
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1285534-86-2
2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1285534-91-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

Guidance literature:: In pyridine; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo101963z

Reference yield:

: C₃₄H₅₂N₆O₉Si₂

: 1285534-91-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

2: pyridine / 3 h / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; pyridine;
DOI:10.1021/jo101963z

Reference yield:

: 1285534-85-1
2'-O-[2-(methoxycarbonyl)ethyl]-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-aminoadenosine

: 1285534-91-9
5'-O-(4,4'-dimethoxytrityl)-2'-O-[2-(N-methylcarbamoyl)ethyl]-2-N-phenoxyacetylguanosine

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; ethanol / 18 h / 20 °C / Inert atmosphere

2: pyridine / -10 - 20 °C / Inert atmosphere

3: sodium nitrite / water; acetic acid / 48.5 h / 20 °C / Inert atmosphere

4: triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 6 h / 20 °C / Inert atmosphere

5: pyridine / 3 h / 20 °C / Inert atmosphere

With triethylamine tris(hydrogen fluoride); triethylamine; sodium nitrite; In tetrahydrofuran; pyridine; methanol; ethanol; water; acetic acid;
DOI:10.1021/jo101963z