(2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide

Base Information

• Chemical Name: (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide
• CAS No.: 207615-11-0
• Molecular Formula: C₁₆H₂₃NOSi
• Molecular Weight: 273.45
• Mol file: 207615-11-0.mol

Synonyms:(2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide

Chemical Property of (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide

There total 2 articles about (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(trimethylsilylmethyl)methylamine (18135-05-2) + 5-phenyl-2,4-pentadienoic acid chloride (100636-30-4) → (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide (207615-11-0)

Guidance literature:

With sodium hydroxide; In benzene; at 40 ℃; for 2h; Yield given;

DOI:10.1248/cpb.46.572

Reference yield:

5-phenylpenta-2,4-dienoic acid (28010-12-0) → (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide (207615-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 3 h / 65 °C

2: 10percent aq. NaOH / benzene / 2 h / 40 °C

With sodium hydroxide; thionyl chloride; In benzene;

DOI:10.1248/cpb.46.572

Reference yield: 95.0%

(2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide (207615-11-0) → Methyl-((2E,4E)-5-phenyl-penta-2,4-dienyl)-trimethylsilanylmethyl-amine (207615-12-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h;

DOI:10.1248/cpb.46.572

upstream raw materials:

N-(trimethylsilylmethyl)methylamine

5-phenyl-2,4-pentadienoic acid chloride

5-phenylpenta-2,4-dienoic acid

Downstream raw materials:

Methyl-((2E,4E)-5-phenyl-penta-2,4-dienyl)-trimethylsilanylmethyl-amine