100636-30-4

Upstream product

• 79-37-8 oxalyl dichloride 
• 28010-12-0 5-phenylpenta-2,4-dienoic acid 
• 14371-10-9 (E)-3-phenylpropenal 
• 100-52-7 benzaldehyde 
• 39806-16-1 ethyl (2E,4E)-5-phenyl-penta-2,4-dienoate 

Downstream Products

• 1720-32-7 1,6-diphenyl-hexa-1,3,5-triene 
• 19222-50-5 1,8-diphenyl-1,3,5,7-octatetraene 
• 80547-46-2 (2E,4E)-5-Phenyl-penta-2,4-dienoic acid (3S,8S,9S,10R,13R,14S,17R)-17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 29179-33-7 8-phenyl-3,5,7-octatrien-2-one 
• 119507-04-9 (3Z,5E,7E)-8-Phenyl-octa-3,5,7-trien-2-one 
• 81620-77-1 7-phenyl-hepta-2,4,6-trienenitrile 
• 119507-03-8 (2Z,4E,6E)-7-Phenyl-hepta-2,4,6-trienenitrile 
• 39806-23-0 ethyl (2E,4E,6E)-7-phenyl-2,4,6-heptatrienoate 
• 119507-02-7 (2Z,4E,6E)-7-Phenyl-hepta-2,4,6-trienoic acid ethyl ester 
• 100636-24-6 dimethyl 1-oxo-5-phenyl-2,4-pentadienephosphonate 
• 58506-33-5 5-phenyl-trans,trans-2,4-pentadien-1-ol 
• 207615-11-0 (2E,4E)-5-Phenyl-penta-2,4-dienoic acid methyl-trimethylsilanylmethyl-amide 
• 670254-21-4 5-phenylpenta-2,4-dienoic acid cyclohexyl amide 
• 21497-23-4 (2E,4E)-N,N-dimethyl-5-phenylpenta-2,4-dienamide 

Relevant academic research and scientific papers

Synthesis and characterization of unsaturated diacyl and alkyl-acyl piperazine derivatives

The aim of this study is to obtain new unsaturated piperazine compounds by the reactions of piperazine (1a) and piperazine derivatives (1b–1d) with acylation reactive groups (2a–2j). Methacryloyl piperazine (1b) was synthesized from the reaction of methacrylic anhydride with piperazine (1a). Acyl chlorides (2b–2d) were prepared from the reaction of thionyl chloride with carboxylic acids (3a–3c) obtained as a result of the reaction with malonic acid and suitable aldehyde (5-methylfuran-2-carbaldehyde for 3a, cinnamaldehyde for 3b, and thiophene-2-carbaldehyde for 3c), respectively, by literature methods. Acyl chlorides 2e and 2f were obtained from the reaction of commercially purchased carboxylic acids 3d and 3e with thionyl chloride. Acyl chlorides (2g–2j) were synthesized from the reaction of thionyl chloride with carboxylic acids (3d–3g) transformed from hydrolyzation of esters (4a–4d) obtained as a result of the reaction of triethyl phosphonoacetate with a suitable ketone (acetophenone for 4a, benzophenone for 4b, 1-(5-methylfuran-2-yl)ethan-1-one for 4c, and 1-(thiophen-2-yl)ethan-1-one for 4d), respectively, by literature methods. Unsaturated piperazine derivatives 5a and 5b were obtained from the reaction of 1b with 2b and 2e, respectively. In addition, from the reaction of 1b and acyl chlorides (2b–2j), unsaturated piperazines (5c–5k) were synthesized in medium to good yields (63%–84%). Also, 5l–5g and 5r–5w were obtained from the reaction of allyl piperazine (2c) and cinnamyl piperazine (2d) with acyl chlorides (2a–2f).

Synthesis of dihydronaphthalenes via aryne Diels-Alder reactions: Scope and diastereoselectivity

Novel aryne Diels-Alder reactions with functionalized acyclic dienes are reported. These give useful cis-substituted dihydronaphthalene building blocks in good yield which are not easily accessible via other means, as demonstrated in the synthesis of sert

Synthetic and spectroscopic studies of structural analogs of piper amides - The 5-aryl-2E,4E-pentadienamides

The methyl esters and piperidides of fourteen 5-aryl-2E,4E-pentadienoic acids have been synthesized starting from the corresponding aryl aldehydes.

Morphinane derivatives and medicinal use thereof

Novel morphinan derivatives and pharmaceutically acceptable acid addition salts thereof as compounds having abilities to bind to opioid ε-receptor, which have agonist or antagonist activities, are disclosed. The morphinan derivatives according to the pres