N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

Base Information

Chemical Name:N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide
CAS No.:1350411-35-6
Molecular Formula:C₂₈H₄₄N₄O
Molecular Weight:452.684
Hs Code.:

Synonyms:N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

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Chemical Property of N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

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Technology Process of N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

There total 7 articles about N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 872-53-7
cyclopentanealdehyde

: 1350411-33-4
2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]-N-piperidin-4-yl-acetamide hydrochloride

: 1350411-35-6
N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 1334001-49-8
4-[2-(4-bromophenyl)acetylamino]piperidine-1-carboxylic acid tert-butyl ester

: 1350411-35-6
N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / dichloromethane; methanol / 1 h / 20 °C

1.2: 6 h / 85 °C / Inert atmosphere

2.1: hydrogenchloride; thiophenol / 1,4-dioxane / 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tris(acetoxy)borohydride; thiophenol; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane;

Reference yield:

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1350411-35-6
N-(1-cyclopentylmethylpiperidin-4-yl)-2-[4-((2S,3'S)-2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 1.25 h / 0 - 20 °C

2.1: potassium hydroxide / dichloromethane; methanol / 1 h / 20 °C

2.2: 6 h / 85 °C / Inert atmosphere

3.1: hydrogenchloride; thiophenol / 1,4-dioxane / 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;