5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine

Base Information

• Chemical Name: 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine
• CAS No.: 1607445-57-7
• Molecular Formula: C₄₆H₄₈N₃O₇
• Molecular Weight: 754.903
• Mol file: 1607445-57-7.mol

Synonyms:5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine

Chemical Property of 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine

There total 2 articles about 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trans-4-methyl-N-(hexene-1-ylboronic acid pinacol ester)quinolinium chloride (1607445-56-6) + 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine (104375-88-4) → 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine (1607445-57-7)

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; for 3h; Reflux;

DOI:10.1016/j.bmc.2014.03.033

Reference yield:

C6H4NCH2CHCCH2 (491-35-0) → 5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine (1607445-57-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / acetonitrile / 96 h / Reflux; Inert atmosphere

2: trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate / acetonitrile; water / 3 h / Reflux

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; sodium iodide; In water; acetonitrile; 2: |Suzuki Coupling;

DOI:10.1016/j.bmc.2014.03.033

Reference yield: 66.0%

5-(trans-4-methyl-N-(hexen-1-yl-)quinolinium)-5'-DMT-uridine (1607445-57-7) + 2-methylthio-3-methylbenzothiazolium iodide (20064-98-6) → C54H53N4O7S(1+) (1607445-58-8)

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2014.03.033

upstream raw materials:

C₆H₄NCH₂CHCCH₂

trans-4-methyl-N-(hexene-1-ylboronic acid pinacol ester)quinolinium chloride

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

Downstream raw materials:

C₅₄H₅₃N₄O₇S⁽¹⁺⁾

C₆₃H₇₀N₆O₈PS⁽¹⁺⁾