4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: 4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
• CAS No.: 227776-28-5
• Molecular Formula: C₁₉H₂₅N₃O₄
• Molecular Weight: 359.425
• Mol file: 227776-28-5.mol

Synonyms:4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;4-[2-(1,3-Dihydro-1,3dioxo-2H-isoindol-yl)ethyl]-1-piperazinecarboxylic acid,1,1-dimethylethyl

Chemical Property of 4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 489.5°Cat760mmHg
• Flash Point: 249.8°C
• PSA: 70.16000
• Density: 1.231g/cm³
• LogP: 1.64900

Purity/Quality:

98%min ^*data from raw suppliers

4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

There total 2 articles about 4-[2-(1,3-DIHYDRO-1,3DIOXO-2H-ISOINDOL-YL)ETHYL]-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

→ tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate (227776-28-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h;

Reference yield: 57.0%

2-(2-bromoethyl)isoindoline-1,3-dione (574-98-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate (227776-28-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃;

DOI:10.1002/cmdc.201300474

Reference yield: 100.0%

tert-butyl 4-(2-(1,3-dioxoisoindolin-2-yl)ethyl)piperazine-1-carboxylate (227776-28-5) → tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate (192130-34-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃;

upstream raw materials:

2-(2-bromoethyl)isoindoline-1,3-dione

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

tert-butyl 4-(2-aminoethyl)piperazine-1-carboxylate

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