N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

Base Information

Chemical Name:N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide
CAS No.:1242163-49-0
Molecular Formula:C₂₀H₂₂N₄O₄S₂
Molecular Weight:446.551
Hs Code.:

Synonyms:N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

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Chemical Property of N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

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Technology Process of N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

There total 7 articles about N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.7%

: 1579938-96-7
C₁₉H₁₈ClN₃O₃S₂

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 1242163-49-0
N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1039/c3ob41936c

Reference yield:

: C₁₉H₁₉N₃O₄S₂

: 1242163-49-0
N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1039/c3ob41936c

Reference yield:

: 1579938-69-4
C₂₁H₂₃N₃O₄S₂

: 1242163-49-0
N-hydroxy-N-methyl-3-(5-(4-(methylsulfonyl)phenyl)-1-p-tolyl-1H-1,2,4-triazol-3-ylthio)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol / 1 h / Reflux

1.2: pH 2

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1039/c3ob41936c