Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)

Base Information

Chemical Name:Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)
CAS No.:227752-45-6
Molecular Formula:C₈H₇NO₂
Molecular Weight:149.149
Hs Code.:
Mol file:227752-45-6.mol

Synonyms:Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)

Suppliers and Price of Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI)

There total 7 articles about Furo[3,2-b]pyridine-6-carboxaldehyde, 2,3-dihydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 227752-44-5
(2,3-dihydrofuro[3,2-b]pyridin-6-yl)methanol

: 227752-45-6
2,3-dihydrofuro[3,2-b]pyridine-6-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 30766-22-4
methyl 5-hydroxy-3-pyridinecarboxylate

: 227752-45-6
2,3-dihydrofuro[3,2-b]pyridine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine; sodium carbonate / tetrahydrofuran; water / 4 h / 20 °C

2.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3.1: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: potassium fluoride / methanol / 2 h / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 60 °C / 3750.38 Torr

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 - 20 °C

7.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

With potassium fluoride; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; iodine; sodium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1189816-87-2
methyl 5-hydroxy-6-iodopyridine-3-carboxylate

: 227752-45-6
2,3-dihydrofuro[3,2-b]pyridine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2.1: tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: potassium fluoride / methanol / 2 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 60 °C / 3750.38 Torr

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 - 20 °C

6.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C

With potassium fluoride; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; dichloromethane;