5-acetoxy-2-acetoxymethylphenol

Base Information

• Chemical Name: 5-acetoxy-2-acetoxymethylphenol
• CAS No.: 218444-35-0
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Mol file: 218444-35-0.mol

Synonyms:5-acetoxy-2-acetoxymethylphenol

Chemical Property of 5-acetoxy-2-acetoxymethylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-acetoxy-2-acetoxymethylphenol

There total 3 articles about 5-acetoxy-2-acetoxymethylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C9H10O4 (1092064-18-0) + acetic anhydride (108-24-7) → 5-acetoxy-2-acetoxymethylphenol (218444-35-0)

Guidance literature:

With boron trifluoride diethyl etherate; regioselective reaction;

DOI:10.1055/s-2008-1078057

Reference yield: 89.0%

2,4-diacetoxybenzaldehyde (41777-08-6) → 5-acetoxy-2-acetoxymethylphenol (218444-35-0)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol7029068

Reference yield:

2,4-Dihydroxybenzaldehyde (95-01-2) → 5-acetoxy-2-acetoxymethylphenol (218444-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / diethyl ether / 0.5 h / 20 °C

2: BH₃-DMS complex / tetrahydrofuran / 0 - 20 °C

With dimethylsulfide borane complex; potassium carbonate; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2006.03.092

upstream raw materials:

2,4-diacetoxybenzaldehyde

2,4-Dihydroxybenzaldehyde

C₉H₁₀O₄

acetic anhydride

Downstream raw materials:

moracin C

2-(3,5-dimethoxyphenyl)-6-hydroxybenzofuran

6-Acetoxy-2-(3',5'-dimethoxyphenyl)benzo[b]furan

2-(3,5-dimethoxyphenyl)-6-(tert-butyl-dimethylsilanyloxy)benzofuran