4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

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Chemical Name:4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide
CAS No.:1236284-89-1
Molecular Formula:C₂₁H₂₁F₂N₇O
Molecular Weight:425.441
Hs Code.:

Synonyms:4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

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Chemical Property of 4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

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Technology Process of 4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

There total 1 articles about 4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 506-68-3
bromocyane

: 1236347-38-8
3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

: 1236284-89-1
4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; ethanol; at 20 ℃; for 16h;

Reference yield: 46.0%

: 1236284-89-1
4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

: 5500-21-0
cyclopropropanecarbonitrile

: 1236284-32-4
4-[7-[1-(3-cyclopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-4-yl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

Guidance literature:: cyclopropropanecarbonitrile; With hydroxylamine; In ethanol; water; for 2.5h; Reflux;

4-[7-(1-cyano-piperidin-4-yl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide; With toluene-4-sulfonic acid; zinc(II) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;