4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

Base Information

Chemical Name:4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide
CAS No.:1422026-19-4
Molecular Formula:C₂₄H₃₂BrN₃O₄S
Molecular Weight:538.506
Hs Code.:

Synonyms:4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

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Chemical Property of 4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

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Technology Process of 4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

There total 9 articles about 4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1422027-60-8
4-{[1-(2-bromo-benzenesulfonylamino)-cyclohexanecarbonyl]-amino}-adamantane-1-carboxylic acid

: 1422026-19-4
4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

Guidance literature:: 4-{[1-(2-bromo-benzenesulfonylamino)-cyclohexanecarbonyl]-amino}-adamantane-1-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.0833333h;

With ammonium hydroxide; In dichloromethane; water;

Reference yield:

: 56674-87-4
4-oxoadamantane-1-carboxylic acid

: 1422026-19-4
4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonia; palladium 10% on activated carbon; hydrogen / methanol / 12 h

2.1: acetyl chloride / 12 h / 20 - 45 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C

4.2: pH 1 - 2

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.08 h / 20 °C

With dmap; palladium 10% on activated carbon; ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; acetyl chloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 1057075-91-8
methyl 4-amino-adamantane-1-carboxylate hydrochloride

: 1422026-19-4
4-{[1-(2-bromobenzenesulfonylamino)cyclohexanecarbonyl]amino}adamantane-1-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C

2.2: pH 1 - 2

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.08 h / 20 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;