Benzenemethanol, 3-amino-4-fluoro- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 3-amino-4-fluoro- (9CI)
• CAS No.: 227609-86-1
• Molecular Formula: C7H8 F N O
• Molecular Weight: 141.145
• Hs Code.: 2906290090
• Mol file: 227609-86-1.mol

Synonyms:(3-Amino-4-fluorophenyl)methanol;3-Amino-4-fluorobenzenemethanol; 3-Amino-4-fluorobenzyl alcohol

Chemical Property of Benzenemethanol, 3-amino-4-fluoro- (9CI)

Chemical Property:

• Melting Point: 76～78℃
• PSA: 46.25000
• LogP: 1.48140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

(3-Amino-4-fluorophenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 3-amino-4-fluoro- (9CI)

There total 7 articles about Benzenemethanol, 3-amino-4-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(4-fluoro-3-nitrophenyl)methanol (20274-69-5) → (3-amino-4-fluorophenyl)methanol (227609-86-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃;

Reference yield: 94.0%

3-amino-4-fluorobenzoic acid (2365-85-7) → (3-amino-4-fluorophenyl)methanol (227609-86-1)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.3762/bjoc.9.219

Reference yield:

4-fluoro-3-nitrobenzaldehyde (42564-51-2) → (3-amino-4-fluorophenyl)methanol (227609-86-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol; water / 20 °C

2: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With sodium tetrahydroborate; palladium on activated charcoal; hydrogen; In methanol; ethanol; water;

DOI:10.1080/09168451.2014.997185

upstream raw materials:

3-amino-4-fluorobenzoic acid

(4-fluoro-3-nitrophenyl)methanol

3-nitro-4-fluorobenzoic acid

4-fluorobenzaldehyde

Downstream raw materials:

(4-fluoro-3-iodophenyl)methanol

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