2-Fluoro-5-(hydroxymethyl)benzonitrile

Base Information

• Chemical Name: 2-Fluoro-5-(hydroxymethyl)benzonitrile
• CAS No.: 227609-85-0
• Molecular Formula: C8H6FNO
• Molecular Weight: 151.14
• Hs Code.: 2926909090
• DSSTox Substance ID: DTXSID70378783
• Nikkaji Number: J1.276.333F
• Wikidata: Q72479986
• Mol file: 227609-85-0.mol

Synonyms:2-fluoro-5-(hydroxymethyl)benzonitrile;227609-85-0;3-Cyano-4-fluorobenzyl alcohol;Benzonitrile, 2-fluoro-5-(hydroxymethyl)- (9CI);2-Fluoro-5-hydroxymethyl-benzonitrile;SCHEMBL2657523;DTXSID70378783;OOVBMNHJMJKTRH-UHFFFAOYSA-N;Fluoro-5-(hydroxymethyl)benzonitrile;CL9309;MFCD03094340;AKOS005259297;BF-0734;A4851;CS-0060348;FT-0682914;EN300-1232069;J-509431

Chemical Property of 2-Fluoro-5-(hydroxymethyl)benzonitrile

Chemical Property:

• Boiling Point: 284.5 °C at 760 mmHg
• PKA: 13.93±0.10(Predicted)
• Flash Point: 125.8 °C
• PSA: 44.02000
• Density: 1.27 g/cm³
• LogP: 1.18968
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 151.043341977
• Heavy Atom Count: 11
• Complexity: 174

Purity/Quality:

97% ^*data from raw suppliers

2-Fluoro-5-(hydroxymethyl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CO)C#N)F

Technology Process of 2-Fluoro-5-(hydroxymethyl)benzonitrile

There total 5 articles about 2-Fluoro-5-(hydroxymethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-fluoro-5-formylbenzonitrile (218301-22-5) → 2-fluoro-5-(hydroxymethyl)benzonitrile (227609-85-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 2h;

Reference yield:

3-cyano-4-fluorobenzoic acid (171050-06-9) → 2-fluoro-5-(hydroxymethyl)benzonitrile (227609-85-0)

Guidance literature:

3-cyano-4-fluorobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

zinc(II) cyanide (557-21-1) + 3-bromo-4-fluoro-benzyl alcohol (77771-03-0) → 2-fluoro-5-(hydroxymethyl)benzonitrile (227609-85-0)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl acetamide; at 150 ℃; for 0.666667h;

upstream raw materials:

2-fluoro-5-formylbenzonitrile

3-bromo-4-fluorobenzaldehyde

3-cyano-4-fluorobenzoic acid

zinc(II) cyanide

Downstream raw materials:

5-bromomethyl-2-fluorobenzonitrile

2-fluoro-5-(hydroxymethyl)benzoic acid

C₁₄H₂₀FNOSi

tert-butyl 4-{3-[(3R)-3-{[(1S)-1-{5-[(3-cyano-4-fluorobenzyl)oxy]pyridin-3-yl}-3-methoxy-3-oxopropyl]carbamoyl}piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate