cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

Base Information

Chemical Name:cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine
CAS No.:80274-13-1
Molecular Formula:C₂₇H₂₈F₂N₂
Molecular Weight:418.53
Hs Code.:

Synonyms:cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

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Chemical Property of cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

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Technology Process of cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

There total 8 articles about cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 103-63-9
1-phenyl-2-bromoethane

: 344551-41-3
1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>piperazine

: 80274-13-1
cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

: 80274-12-0
trans-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

Guidance literature:: With potassium carbonate; In various solvent(s); for 16h; Heating;
DOI:10.1021/jm00361a002

Reference yield:

: 80272-38-4
3-(4-fluorophenyl)-6-(trifluoromethyl)indan-1-one

: 80274-13-1
cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / sodium borohydride / methanol / 1 h / Ambient temperature

2: 100 percent / SOCl₂ / toluene / 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h

3: 94 percent / butan-2-one / 3 h / Heating

4: 9.6 percent / K₂CO₃ / various solvent(s) / 16 h / Heating

With sodium tetrahydroborate; thionyl chloride; potassium carbonate; In methanol; toluene; butanone;
DOI:10.1021/jm00361a002

Reference yield:

: 85118-24-7
2-bromo-4-(trifluoromethyl)benzaldehyde

: 80274-13-1
cis-1-<6-fluoro-3-(4-fluorophenyl)indan-1-yl>-4-(2-phenylethyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / piperidine / toluene / 0.5 h / Heating

2: 1.) Mg / 1.) ether, 2.) ether, toluene, reflux, 30 min

3: aq. H₂SO₄, CH₃COOH / 24 h / Heating

4: 82 percent / n-butyllithium / hexane; diethyl ether / 0.5 h / 0 °C

5: 75 percent / sodium borohydride / methanol / 1 h / Ambient temperature

6: 100 percent / SOCl₂ / toluene / 1.) RT, 30 min, 2.) from 50 deg C to 55 deg C, 1 h

7: 94 percent / butan-2-one / 3 h / Heating

8: 9.6 percent / K₂CO₃ / various solvent(s) / 16 h / Heating

With piperidine; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sulfuric acid; potassium carbonate; magnesium; acetic acid; In methanol; diethyl ether; hexane; toluene; butanone;
DOI:10.1021/jm00361a002