2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

Base Information

Chemical Name:2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid
CAS No.:1168111-72-5
Molecular Formula:C₂₂H₂₃ClN₂O₄
Molecular Weight:414.889
Hs Code.:

Synonyms:2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

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Chemical Property of 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

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Technology Process of 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

There total 7 articles about 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1168134-92-6
ethyl 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

: 1168111-72-5
2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

Guidance literature:: ethyl 2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate; With methanol; water; lithium hydroxide; In tetrahydrofuran; at 20 - 25 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃;

Reference yield:

: 17138-28-2
(4-hydroxy-phenyl)-acetic acid ethyl ester

: 1168111-72-5
2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux

2.1: bromine / chloroform / 1 h / 0 °C

3.1: potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 1 h / 0 °C

5.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 80 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; lithium hydroxide monohydrate; water; bromine; sodium hydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 193357-36-7
3-chloro-4-hydroxyphenylacetic acid ethyl ester

: 1168111-72-5
2-(3-(benzo[c][1,2,5]oxadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / chloroform / 1 h / 0 °C

2.1: potassium carbonate / dimethyl sulfoxide / 4 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 1 h / 0 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 14 h / 80 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; bromine; sodium hydride; potassium carbonate; caesium carbonate; In tetrahydrofuran; methanol; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide;