3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester
• CAS No.: 303155-00-2
• Molecular Formula: C₁₂H₁₈O₄
• Molecular Weight: 226.273
• Mol file: 303155-00-2.mol

Synonyms:3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester

Chemical Property of 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester

There total 3 articles about 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

hydrogen ethyl malonate (1071-46-1) + 1-methyl-2-oxocyclohexanecarboxylic acid chloride (134519-26-9) → 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester (303155-00-2)

Guidance literature:

hydrogen ethyl malonate; With isopropylmagnesium bromide; In tetrahydrofuran; dichloromethane; at 40 - 50 ℃;

1-methyl-2-oxocyclohexanecarboxylic acid chloride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(00)00569-X

Reference yield:

ethyl 1-methyl-2-oxocyclohexancarboxylate (66088-37-7,5453-94-1) → 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester (303155-00-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: aq. KOH / 20 °C

2.1: (COCl)2 / diethyl ether / 2 h / 25 °C

3.1: i-PrMgBr / CH₂Cl₂; tetrahydrofuran / 40 - 50 °C

3.2: CH₂Cl₂ / 1 h / cooling

With potassium hydroxide; oxalyl dichloride; isopropylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jo0256134

Reference yield:

1-methyl-2-oxocyclohexanecarboxylic acid (32116-62-4,152212-38-9,152212-62-9) → 3-(1-methyl-2-oxo-cyclohexyl)-3-oxo-propionic acid ethyl ester (303155-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: (COCl)2 / diethyl ether / 2 h / 25 °C

2.1: i-PrMgBr / CH₂Cl₂; tetrahydrofuran / 40 - 50 °C

2.2: CH₂Cl₂ / 1 h / cooling

With oxalyl dichloride; isopropylmagnesium bromide; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/jo0256134

upstream raw materials:

hydrogen ethyl malonate

1-methyl-2-oxocyclohexanecarboxylic acid chloride

ethyl 1-methyl-2-oxocyclohexancarboxylate

1-methyl-2-oxocyclohexanecarboxylic acid

Downstream raw materials:

2-diazo-3-(1-methyl-2-oxocyclohexyl)-3-oxopropanoic acid ethyl ester