7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Base Information

Chemical Name:7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one
CAS No.:137022-91-4
Molecular Formula:C₁₈H₁₅Br₂N₃O₂
Molecular Weight:465.144
Hs Code.:

Synonyms:7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Chemical Property of 7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

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Technology Process of 7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

There total 43 articles about 7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 134755-34-3
3,5-dibromo-4-hydroxy-β-phenethylamine

: 160208-44-6
7-Methoxy-2,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one

: 137022-91-4
7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: With sodium carbonate; In ethanol; for 3h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85065-1

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 137022-91-4
7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 14 steps

1: K₂CO₃ / ethanol / 10 h / Heating

2: NaOEt / ethanol; tetrahydrofuran / a) -15 deg C, 3 h, b) 4 deg C, 12 h

3: xylene / 3 h / Heating

4: 93 percent / KOH / ethanol / 1.5 h / Heating

5: 73 percent / copper chromite / quinoline / 3 h / 230 °C

6: acetic acid / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) iodomethane / 1.) THF, from 0 deg C to 4 deg C, 30 h, 2.) water, 80 deg C, 3.5 h

8: H₂, NH₃ / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature

9: 1.) NaOEt / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, RT, 3 h

10: H₂ / 10percent Pd/C / ethanol / 48 h / 2508 Torr / Ambient temperature

11: Fremy's salt, aq. KH₂PO₄ / acetone / 4 h / 0 °C

12: 1.) t-BuOK / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 3 h

13: p-toluenesulfonic acid / acetonitrile / 5 h / Ambient temperature

14: NaHCO₃ / ethanol / 3 h / Heating

With potassium hydroxide; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; copper chromite; potassium tert-butylate; ammonia; hydrogen; sodium ethanolate; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; methyl iodide; palladium on activated charcoal; nickel; In tetrahydrofuran; quinoline; ethanol; dichloromethane; acetone; acetonitrile; xylene;

Reference yield:

: 32884-23-4
2-benzyloxy-4-methoxybenzaldehyde

: 137022-91-4
7-<<2-(3,5-dibromo-4-hydroxyphenyl)ethyl>amino>-1,3,4,8-tetrahydropyrrolo<4,3,2-de>quinolin-8-one

Guidance literature:: Multi-step reaction with 13 steps

1: NaOEt / ethanol; tetrahydrofuran / a) -15 deg C, 3 h, b) 4 deg C, 12 h

2: xylene / 3 h / Heating

3: 93 percent / KOH / ethanol / 1.5 h / Heating

4: 73 percent / copper chromite / quinoline / 3 h / 230 °C

5: acetic acid / CH₂Cl₂ / 2 h / Ambient temperature

6: 1.) iodomethane / 1.) THF, from 0 deg C to 4 deg C, 30 h, 2.) water, 80 deg C, 3.5 h

7: H₂, NH₃ / Raney nickel / ethanol / 48 h / 2508 Torr / Ambient temperature

8: 1.) NaOEt / 1.) ethanol, 0 deg C, 1 h, 2.) ethanol, RT, 3 h

9: H₂ / 10percent Pd/C / ethanol / 48 h / 2508 Torr / Ambient temperature

10: Fremy's salt, aq. KH₂PO₄ / acetone / 4 h / 0 °C

11: 1.) t-BuOK / 1.) THF, 0 deg C, 1 h, 2.) THF, RT, 3 h

12: p-toluenesulfonic acid / acetonitrile / 5 h / Ambient temperature

13: NaHCO₃ / ethanol / 3 h / Heating

With potassium hydroxide; potassium dihydrogenphosphate; potassiuim nitrosodisulfonate; copper chromite; potassium tert-butylate; ammonia; hydrogen; sodium ethanolate; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; methyl iodide; palladium on activated charcoal; nickel; In tetrahydrofuran; quinoline; ethanol; dichloromethane; acetone; acetonitrile; xylene;