L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER

Base Information

• Chemical Name: L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER
• CAS No.: 227205-81-4
• Molecular Formula: C₇H₈O₃S*C₁₉H₂₁NO₄
• Molecular Weight: 499.585
• Mol file: 227205-81-4.mol

Synonyms:L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER

Chemical Property of L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER

Chemical Property:

• Boiling Point: 453.5°Cat760mmHg
• Flash Point: 165.6°C
• PSA: 141.37000
• Density: g/cm³
• LogP: 5.60350

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER

There total 4 articles about L-GLUTAMIC ACID, BIS PHENYLMETHYL ESTER, 4-METHYL BENZENESULFONATE HOMOPOLYMER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → L-glutamic acid dibenzyl ester 4-toluenesulfonate (2791-84-6,227205-81-4)

Guidance literature:

In benzene; for 7h; Reflux;

DOI:10.1016/j.ejmech.2008.01.032

Reference yield: 83.0%

D-Glutamic acid (6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → D-glutamic acid dibenzyl ester p-toluenesufonate salt (2791-84-6,19898-41-0,120538-51-4,227205-81-4)

Guidance literature:

In benzene; for 7h; Reflux;

DOI:10.1016/j.ejmech.2008.01.032

Reference yield: 81.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + p-toluenesulfonyl chloride (98-59-9) + benzyl alcohol (100-51-6,185532-71-2) → L-glutamic acid dibenzyl ester 4-toluenesulfonate (2791-84-6,227205-81-4)

Guidance literature:

In cyclohexane; for 24h; Reflux;

DOI:10.1007/s10989-019-09998-x

upstream raw materials:

L-glutamic acid

benzyl alcohol

toluene-4-sulfonic acid

p-toluenesulfonyl chloride

Downstream raw materials:

Boc-Glu(OBzl)3-OBzl

Refernces

• 1、 Griffith, Corey M.,Feceu, Abigail,Larive, Cynthia K.,Martin, David B. C.. "Synthesis and structure reassignment of malylglutamate, a recently discovered earthworm metabolite". . p. 417 - 421. Retrieved 2019/02/19.
• 2、 Du, Zuyin,Lu, Yanhui,Dai, Xuedong,Negrerie, Daisy Zhang,Gao, Qingzhi. "The discovery of a facile access to the synthesis of NSAID dendritic prodrugs". . p. 177 - 180. Retrieved 2013/07/05.