(1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

Base Information

• Chemical Name: (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol
• CAS No.: 1218781-83-9
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423
• Mol file: 1218781-83-9.mol

Synonyms:(1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

Chemical Property of (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

Chemical Property:

Purity/Quality:

98% min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol

There total 11 articles about (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

benzyloxyacetoaldehyde (60656-87-3) + (S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol (686776-27-2) → (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol (1218781-83-9)

Guidance literature:

With acetic acid; In dichloromethane; 2,2,2-trifluoroethanol; at -10 - 0 ℃; for 8h; Molecular sieve;

Reference yield: 89.0%

benzyloxyacetoaldehyde (60656-87-3) + (S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol (686776-27-2) → (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-8-methyl-1,2,3,4-tetra-hydroisoquinolin-6-ol (1218781-84-0) + (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol (1218781-83-9)

Guidance literature:

With acetic acid; In dichloromethane; 2,2,2-trifluoroethanol; at -10 - 0 ℃; for 10h; regioselective reaction; Molecular sieve;

DOI:10.1021/np400538q

Reference yield:

benzyloxyacetoaldehyde (60656-87-3) + (S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol (686776-27-2) → (1R,3S)-1-(benzyloxymethyl)-3-(hydroxyl-methyl)-7-methoxy-6-methyl-1,2,3,4-tetra-hydroisoquinolin-8-ol (1218781-83-9) + C20H25NO4

Guidance literature:

With acetic acid; In dichloromethane; 2,2,2-trifluoroethanol; at 0 ℃; for 7h; Molecular sieve;

DOI:10.1016/j.tet.2015.04.064

upstream raw materials:

benzyloxyacetoaldehyde

(S)-5-(2-amino-3-hydroxypropyl)-2-methoxy-3-methylphenol

(S)-methyl-2-acetamido-3-(3-formyl-4-methoxy-3-methylphenyl)propanoate

(S)-methyl-2-acetamido-3-(3-hydroxy-4-methoxy-5-methylphenyl)propanoate

Downstream raw materials:

(-)-MY 336a

C₄₈H₇₃BrN₂O₉Si₂

C₃₆H₄₅BrN₂O₉

C₃₆H₄₆N₂O₉