Technology Process of (3aR,7aS)-benzyl 3a-(2-tert-butoxy-2-oxoethyl)-tetrahydropyrano[3,4-c]pyrrole-2(1H,3H,6H)-carboxylate
There total 9 articles about (3aR,7aS)-benzyl 3a-(2-tert-butoxy-2-oxoethyl)-tetrahydropyrano[3,4-c]pyrrole-2(1H,3H,6H)-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lead(IV) acetate;
at 80 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C
2.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 0 °C / Inert atmosphere
2.2: 0.5 h
3.1: lead(IV) tetraacetate / 1 h / 80 °C / Inert atmosphere
With
lead(IV) tetraacetate; 1,1'-carbonyldiimidazole; trifluoroacetic acid;
In
dichloromethane; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00644
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium tetrahydroborate / water; tetrahydrofuran; ethyl acetate / 10 h / 20 °C / Inert atmosphere
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 0.5 h / -10 °C / Inert atmosphere
2.2: 10 h / 40 °C / Inert atmosphere
3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 24 h / 38002.6 Torr
4.1: borane-THF / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere
4.2: 2 h / 80 °C / Inert atmosphere
4.3: 24 h / 40 °C
5.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C
6.1: 1,1'-carbonyldiimidazole / acetonitrile / 1 h / 0 °C / Inert atmosphere
6.2: 0.5 h
7.1: lead(IV) tetraacetate / 1 h / 80 °C / Inert atmosphere
With
sodium tetrahydroborate; borane-THF; palladium 10% on activated carbon; hydrogen; lead(IV) tetraacetate; methanesulfonyl chloride; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; acetonitrile;
DOI:10.1021/acs.jmedchem.8b00644
