tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

Base Information

Chemical Name:tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester
CAS No.:1315592-03-0
Molecular Formula:C₁₆H₂₂ClN₃O₃
Molecular Weight:339.822
Hs Code.:

Synonyms:tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

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Chemical Property of tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

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Technology Process of tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

There total 4 articles about tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 104-12-1
p-chlorphenylisocyanate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1315592-03-0
tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

Guidance literature:: In diethyl ether; at 20 ℃; for 3h;

Reference yield: 89.0%

: 106-47-8
4-chloro-aniline

: 7693-46-1
4-Nitrophenyl chloroformate

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1315592-03-0
tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1016/j.ejmech.2018.12.064

Reference yield:

: N-(4-chlorophenyl)thiomorpholine-4-carboxamide 1,1-dioxide

: 1315592-03-0
tert-butyl 4-(4-chlorophenylcarbamoyl)piperazine-1-carboxylic acid ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: diethyl ether / 3 h / 20 °C

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide;