(+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Base Information

Chemical Name:(+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline
CAS No.:1092116-55-6
Molecular Formula:C₂₃H₂₀F₃NO
Molecular Weight:383.413
Hs Code.:

Synonyms:(+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Suppliers and Price of (+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of (+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

There total 2 articles about (+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1092116-43-2
C₃₀H₂₈F₃NO₂S

: 1092116-55-6
(+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/anie.200802885

Reference yield: 55.0%

: 202869-51-0
4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine

: 302934-10-7
(S)-1-ethyl-2-(p-tolylsulfinyl)benzene

: 1092116-55-6
(+)-(2R,3S)-1-(4-methoxyphenyl)-3-methyl-2-phenyl-2-(trifluoromethyl)indoline

Guidance literature:: (S)-1-ethyl-2-(p-tolylsulfinyl)benzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.75h; optical yield given as %de; stereoselective reaction;
DOI:10.1002/anie.200802885