4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine

Base Information

• Chemical Name: 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine
• CAS No.: 202869-51-0
• Molecular Formula: C₁₅H₁₂F₃NO
• Molecular Weight: 279.262
• Mol file: 202869-51-0.mol

Synonyms:4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine

Chemical Property of 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine

There total 6 articles about 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-methoxyphenyl)trifluoroacetimidoyl chloride (75999-66-5) + phenylboronic acid (98-80-6) → 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine (202869-51-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate tribasic trihydrate; In toluene; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2010.04.011

Reference yield: 85.0%

2,2,2-Trifluoroacetophenone (434-45-7) + 4-methoxy-aniline (104-94-9) → 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine (202869-51-0)

Guidance literature:

With fly-ash:H₂SO₄; In neat (no solvent); Reagent/catalyst; Microwave irradiation; Green chemistry;

DOI:10.4067/S0717-97072013000400071

Reference yield: 84.0%

2,2,2-Trifluoroacetophenone (434-45-7) + 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline (14796-89-5) → 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine (202869-51-0)

Guidance literature:

In toluene; at 120 ℃; for 24h;

DOI:10.1002/anie.201103240

upstream raw materials:

2,2,2-Trifluoroacetophenone

4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

p-methoxy-phenylazide

4-methoxy-aniline

Downstream raw materials:

(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-phenylpropanenitrile

(S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline

(R)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline

3,3,3-trifluoro-1-(furan-2-yl)-2-(4-methoxyphenylamino)-2-phenylpropan-1-one