1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

Base Information

Chemical Name:1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone
CAS No.:1428478-62-9
Molecular Formula:C₁₅H₁₇N₅O₂
Molecular Weight:299.332
Hs Code.:

Synonyms:1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

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Chemical Property of 1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

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Technology Process of 1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

There total 1 articles about 1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 289037-48-5
(3-azabicyclo[3.1.0]hex-6-yl)methanol

: 462068-57-1
2-[4-(1H-1,2,3,4-tetrazol-1-ol)phenyl]acetic acid

: 1428478-62-9
1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

Guidance literature:: 2-[4-(1H-1,2,3,4-tetrazol-1-ol)phenyl]acetic acid; With 1,2-dichloro-ethane; In dichloromethane; at 0 - 20 ℃; for 0.25h;

(3-azabicyclo[3.1.0]hex-6-yl)methanol; With triethylamine; In dichloromethane; for 12h;

Reference yield:

: 1428478-62-9
1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

: C₁₅H₁₅N₅O₂

Guidance literature:: 1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone; With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; sodium thiosulfate; In dichloromethane; water; for 0.5h;

Reference yield:

: 1428478-62-9
1-[6-(hydroxymethyl)-3-azabicyclo[3.1.0]hex-3-yl]-2-[4-(1H-tetrazol-1-yl)phenyl] ethanone

: 1428478-61-8
1-(6-ethynyl-3-azabicyclo[3.1.0]hex-3-yl)-2-[4-(1H-tetrazol-1-yl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

2: dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate / methanol / 12 h / 20 °C

With dimethyl 1-(1-diazo-2-oxopropyl)phosphonate; potassium carbonate; Dess-Martin periodane; In methanol; dichloromethane;