N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Base Information

• Chemical Name: N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine
• CAS No.: 1384980-50-0
• Molecular Formula: C₁₈H₂₂N₂O₃S
• Molecular Weight: 346.45
• Mol file: 1384980-50-0.mol

Synonyms:N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Chemical Property of N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

There total 8 articles about N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2,2-dimethyl-3-(4-methoxyphenyl)propionic acid (29206-06-2) + imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9) → N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-50-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol301579q

Reference yield:

C12H15ClO2 + imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9) → N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-50-0)

Guidance literature:

imino(methyl)(pyridin-2-yl)-λ⁶-sulfanone; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

C₁₂H₁₅ClO₂; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol301579q

Reference yield:

N-[2,2-dimethyl-3-phenylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-51-1) → N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: [bis(acetoxy)iodo]benzene; palladium diacetate / acetic anhydride / 28 h / 70 °C

2.1: hydrogenchloride; water / 6 h / 50 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3.2: 12 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; [bis(acetoxy)iodo]benzene; water; palladium diacetate; triethylamine; In dichloromethane; acetic anhydride;

DOI:10.1021/ol301579q

upstream raw materials:

2-Sulfanylpyridine

2-methylsulfanyl-pyridine

2-methylsulfinylpyridine

N-(4-nitrobenzenesulfonyl) methyl (2-pyridinyl) sulfoximine

Downstream raw materials:

N-[3-acetoxy-2-(4-methoxybenzyl)-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine