4-Methoxy-a,a-dimethylbenzenepropanoic acid

Base Information

• Chemical Name: 4-Methoxy-a,a-dimethylbenzenepropanoic acid
• CAS No.: 29206-06-2
• Molecular Formula: C₁₂H₁₆O₃
• Molecular Weight: 208.257
• Mol file: 29206-06-2.mol

Synonyms:4-Methoxy-a,a-dimethylbenzenepropanoic acid;3-(4-methoxyphenyl)-2,2-dimethylpropanoic acid

Chemical Property of 4-Methoxy-a,a-dimethylbenzenepropanoic acid

Chemical Property:

• PSA: 46.53000
• LogP: 2.34850

Purity/Quality:

99.90% ^*data from raw suppliers

2,2-Dimethyl-3-(4-methoxyphenyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,2-Dimethyl-3-(4-methoxyphenyl)propanoic acid is used in biological studies to analyze the effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes.

Technology Process of 4-Methoxy-a,a-dimethylbenzenepropanoic acid

There total 8 articles about 4-Methoxy-a,a-dimethylbenzenepropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2,2-dimethyl-3-(4-methoxyphenyl)propanoate (1035155-37-3) → 2,2-dimethyl-3-(4-methoxyphenyl)propionic acid (29206-06-2)

Guidance literature:

ethyl 2,2-dimethyl-3-(4-methoxyphenyl)propanoate; With potassium tert-butylate; water; In tetrahydrofuran; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield:

methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate (14248-23-8) → 2,2-dimethyl-3-(4-methoxyphenyl)propionic acid (29206-06-2)

Guidance literature:

methyl 3-(4-methoxyphenyl)-2,2-dimethylpropanoate; With water; sodium hydroxide; In methanol; at 60 ℃;

With hydrogenchloride; In methanol; water; pH=2;

DOI:10.1021/ja2001709

Reference yield:

p-methoxybenzyl chloride (824-94-2) + isobutyric Acid (79-31-2) → 2,2-dimethyl-3-(4-methoxyphenyl)propionic acid (29206-06-2)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, RT, overnight;

DOI:10.1021/jm00347a010

upstream raw materials:

3-(4-methoxy-phenyl)-2,2-dimethyl-propionic acid amide

p-methoxybenzyl chloride

isobutyric Acid

ethyl 2,2-dimethyl-3-(4-methoxyphenyl)propanoate

Downstream raw materials:

1-(2-amino-2-methylpropyl)-4-methoxybenzene

2-(4-methoxy-phenyl)-1,1-dimethyl-ethyl isocyanate

1--1,1-dimethyl-2-(4-methoxyphenyl)ethane

3-(4-methoxyphenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide