[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

Base Information

Chemical Name:[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester
CAS No.:862490-67-3
Molecular Formula:C₃₉H₅₇N₇O₉SSi₂
Molecular Weight:856.16
Hs Code.:

[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

Synonyms:[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

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Chemical Property of [[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

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Technology Process of [[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

There total 7 articles about [[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 313497-39-1
2-nitrobenzenesulfonyl glycine ethyl ester

: 862490-67-3
[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 5 h / 50 °C

2: 99 percent / DIEA / 2-methyl-propan-2-ol / 20 h / 85 °C

3: MeOH; NaOMe / 20 °C

4: 1.95 g / imidazole / dimethylformamide / 3 h

With 1H-imidazole; methanol; sodium methylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Mitsunobu reaction;
DOI:10.1021/jo050205w

Reference yield:

: 862490-66-2
C₃₄H₂₉ClN₆O₁₁S

: 862490-67-3
[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / DIEA / 2-methyl-propan-2-ol / 20 h / 85 °C

2: MeOH; NaOMe / 20 °C

3: 1.95 g / imidazole / dimethylformamide / 3 h

With 1H-imidazole; methanol; sodium methylate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jo050205w

Reference yield:

: 862490-76-4
C₄₁H₃₇N₇O₁₁S

: 862490-67-3
[[(2R,3R,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-bis-triethylsilanyloxy-tetrahydro-furan-2-ylmethyl]-(2-nitro-benzenesulfonyl)-amino]-acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: MeOH; NaOMe / 20 °C

2: 1.95 g / imidazole / dimethylformamide / 3 h

With 1H-imidazole; methanol; sodium methylate; In N,N-dimethyl-formamide;
DOI:10.1021/jo050205w