N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide

Base Information

• Chemical Name: N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide
• CAS No.: 1101891-14-8
• Molecular Formula: C₁₄H₆Cl₃F₆N₃O
• Molecular Weight: 452.571

Synonyms:N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide

Chemical Property of N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide

There total 4 articles about N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,3,3-trichloroacrylic acid (2257-35-4) + 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline (123066-64-8) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide (1101891-14-8)

Guidance literature:

With phosphorus trichloride; In acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.1021/jo2009824

Reference yield:

1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one (1694-30-0) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide (1101891-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: phosphorus trichloride / acetonitrile / 0.08 h / 150 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; cyclohexene; phosphorus trichloride; In ethanol; water; acetonitrile;

DOI:10.1021/jo2009824

Reference yield:

4-nitrophenylhydrazine hydrochloride (636-99-7) → N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-2,3,3-trichloroacrylamide (1101891-14-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: phosphorus trichloride / acetonitrile / 0.08 h / 150 °C / Microwave irradiation

With hydrogenchloride; palladium 10% on activated carbon; cyclohexene; phosphorus trichloride; In ethanol; water; acetonitrile;

DOI:10.1021/jo2009824

upstream raw materials:

2,3,3-trichloroacrylic acid

4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one

4-nitrophenylhydrazine hydrochloride

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