N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

Base Information

Chemical Name:N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide
CAS No.:121731-66-6
Molecular Formula:C₁₆H₂₃NO₃S
Molecular Weight:309.43
Hs Code.:

Synonyms:N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

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Chemical Property of N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

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Technology Process of N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

There total 6 articles about N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121731-64-4
ethyl 3-amino>propanoate

: 121731-66-6
N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 2h;
DOI:10.1021/jo00278a024

Reference yield:

: 58561-04-9
N-tert-butoxycarbonyl-L-valine methyl ester

: 121731-66-6
N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminum hydride (DIBAL) / toluene; hexane / 1.5 h / -78 °C

2: 1.) zinc, AlMe₃ / 1.) THF, hexane, 25 deg C, 15 min, 2.) -30 to -20 deg C, 5 h

3: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

4: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

5: K₂CO₃ / acetonitrile / 12 h / Heating

6: diisobutylaluminum hydride (DIBAL) / toluene; hexane / 2 h / -78 °C

With trimethylaluminum; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; zinc; In hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00278a024

Reference yield:

: 79069-51-5
(S)-N-tert-butoxycarbonylvalinal

: 121731-66-6
N-(2-formylethyl)-N-<(1'S)-1'-isopropyl-2'-propenyl>-p-toluenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) zinc, AlMe₃ / 1.) THF, hexane, 25 deg C, 15 min, 2.) -30 to -20 deg C, 5 h

2: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 12 h / Ambient temperature

4: K₂CO₃ / acetonitrile / 12 h / Heating

5: diisobutylaluminum hydride (DIBAL) / toluene; hexane / 2 h / -78 °C

With trimethylaluminum; diisobutylaluminium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; zinc; In hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo00278a024