Technology Process of 2-[(4R,5S)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-benzaldehyde
There total 11 articles about 2-[(4R,5S)-2,2-Dimethyl-5-(6,6,8-trimethyl-1,4-dithia-spiro[4.5]dec-7-en-7-yl)-[1,3]dioxolan-4-yl]-benzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) PdCl2, PPh3, CuI, Et2NH, 2.) imidazole / 1.) 25 deg C
2: 1.) NaOH, 2.) H2, quinoline / Lindlar cat. / 1.) benzene, reflux
3: (DHQD)2-PHAL, K2OsO2(OH)4, K3Fe(CN)6, K2CO3 / H2O; 2-methyl-propan-2-ol
4: 1.) py, 2.) PPTS
5: 1.) LiAlH4, 2.) (COCl)2, Et3N / 2.) DMSO, CH2Cl2, -78 deg C
6: tetrahydrofuran / -78 °C
7: PPTS
8: TBAF / tetrahydrofuran
9: MnO2
With
pyridine; 1H-imidazole; quinoline; manganese(IV) oxide; sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; oxalyl dichloride; potassium dioxotetrahydroxoosmate(VI); tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; diethylamine; triethylamine; triphenylphosphine; palladium dichloride; potassium hexacyanoferrate(III);
Lindlar catalyst;
In
tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)73292-8
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) NaOH, 2.) H2, quinoline / Lindlar cat. / 1.) benzene, reflux
2: (DHQD)2-PHAL, K2OsO2(OH)4, K3Fe(CN)6, K2CO3 / H2O; 2-methyl-propan-2-ol
3: 1.) py, 2.) PPTS
4: 1.) LiAlH4, 2.) (COCl)2, Et3N / 2.) DMSO, CH2Cl2, -78 deg C
5: tetrahydrofuran / -78 °C
6: PPTS
7: TBAF / tetrahydrofuran
8: MnO2
With
pyridine; quinoline; manganese(IV) oxide; sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; potassium dioxotetrahydroxoosmate(VI); tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; triethylamine; potassium hexacyanoferrate(III);
Lindlar catalyst;
In
tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(00)73292-8
