Technology Process of 5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene
There total 2 articles about 5,5-(ethylenedioxy)-2,,6,6-trimethyl-1-iodocyclohexene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 88 percent / (+/-)-camphor-10-sulfonic acid / benzene / 0.5 h / Heating
2.1: LiHMDS / hexane; tetrahydrofuran / 1 h / -78 °C
2.2: 89 percent / hexane; tetrahydrofuran / 3.5 h / -78 - 20 °C
3.1: hydrazine hydrate; triethylamine / ethanol / 312 h / Heating
4.1: 9.2 g / DBN; I2 / diethyl ether / 0.5 h / 20 °C
With
2,6-dichloro-benzonitrile; camphor-10-sulfonic acid; iodine; hydrazine hydrate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; benzene;
DOI:10.1016/S0040-4020(03)00699-9
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: (1S)-(+)-10-camphorsulfonic acid / toluene / 14 h / 50 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 3 h / -78 - 20 °C
3.1: hydrazine hydrate; triethylamine / ethanol / 168 h / 100 °C
4.1: iodine; DBN / diethyl ether / 1 h / 0 - 20 °C
With
DBN; iodine; (1S)-(+)-10-camphorsulfonic acid; hydrazine hydrate; triethylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethyl ether; ethanol; toluene;
DOI:10.1002/anie.201906872
