meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole

Base Information

• Chemical Name: meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole
• CAS No.: 944253-11-6
• Molecular Formula: C₂₂H₁₉Cl₂N₃O
• Molecular Weight: 412.318
• Mol file: 944253-11-6.mol

Synonyms:meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole

Chemical Property of meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole

There total 1 articles about meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine (86212-34-2,91044-20-1,98674-96-5,74641-30-8) + 2-Ethoxypyridine-3-carboxylic Acid Ethyl Ester (15441-51-7) → meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole (944253-11-6)

Guidance literature:

(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine; trimethylaluminum; In toluene; at 0 - 90 ℃; for 1.75h;

2-Ethoxypyridine-3-carboxylic Acid Ethyl Ester; In toluene; for 2h; Heating / reflux;

Reference yield:

phosgene (75-44-5) + meso-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole (944253-11-6) → 4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride

Guidance literature:

With triethylamine; In dichloromethane; toluene; at 0 ℃; for 0.5h;

upstream raw materials:

(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine

2-Ethoxypyridine-3-carboxylic Acid Ethyl Ester