(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

Base Information

Chemical Name:(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester
CAS No.:312305-50-3
Molecular Formula:C₂₄H₃₄O₆
Molecular Weight:418.53
Hs Code.:

Synonyms:(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

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Chemical Property of (S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

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Technology Process of (S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

There total 24 articles about (S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 74-85-1
ethene

: 312305-49-0
(S)-2,4-dimethoxy-6-trifluoromethanesulfonyloxy-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

: 312305-50-3
(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; triethylamine; lithium chloride; In N,N-dimethyl-formamide; at 90 ℃; for 20h; under 30003 Torr;
DOI:10.1021/jo0009999

Reference yield: 82.0%

: 1044598-19-7
(S)-5-(2-(pent-4-enyl)-1,3-dioxolan-2-yl)pentan-2-ol

: 1449688-77-0
2,4-dimethoxy-6-vinylbenzoyl fluoride

: 312305-50-3
(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.bmc.2013.06.024

Reference yield:

: 21889-88-3
hept-6-en-2-one

: 312305-50-3
(S)-2,4-dimethoxy-6-vinyl-benzoic acid 1-methyl-4-(2-pent-4-enyl-[1,3]dioxolan-2-yl)-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / ethanol / Reflux

2.1: n-butyllithium / tetrahydrofuran / 0 °C

2.2: 0 °C

3.1: toluene-4-sulfonic acid / benzene / 80 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran

5.1: potassium hexamethylsilazane / tetrahydrofuran / 0 °C

With n-butyllithium; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; ethanol; benzene;
DOI:10.1016/j.bmc.2013.06.024