(hydroxy)acetic acid

Base Information

• Chemical Name: (hydroxy)acetic acid
• CAS No.: 158212-99-8
• Molecular Formula: C₁₂H₁₉NO₅
• Molecular Weight: 257.287
• Mol file: 158212-99-8.mol

Synonyms:(hydroxy)acetic acid

Chemical Property of (hydroxy)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (hydroxy)acetic acid

There total 2 articles about (hydroxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

Methyl glyoxylate (922-68-9) + methyl N-(2-cyclohexen-1-ylmethyl)carbamate (40391-15-9) → (hydroxy)acetic acid (158212-99-8)

Guidance literature:

In benzene;

DOI:10.1016/S0040-4020(01)81240-0

Reference yield:

3-(trimethylsilyl)cyclohexene (40934-71-2) → (hydroxy)acetic acid (158212-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / BF₃*OEt₂ / CH₂Cl₂

2: 68 percent / benzene

With boron trifluoride diethyl etherate; In dichloromethane; benzene;

DOI:10.1016/S0040-4020(01)81240-0

Reference yield: 100.0%

(hydroxy)acetic acid (158212-99-8) → chloro-(cyclohex-2-enylmethyl-methoxycarbonyl-amino)-acetic acid methyl ester

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane; for 0.333333h;

DOI:10.1016/S0040-4020(01)80863-2

upstream raw materials:

Methyl glyoxylate

methyl N-(2-cyclohexen-1-ylmethyl)carbamate

3-(trimethylsilyl)cyclohexene

Downstream raw materials:

acetoxyacetic acid

(phenylthio)acetic acid methyl ester