4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYLBORON&

Base Information

• Chemical Name: 4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYLBORON&
• CAS No.: 226396-30-1
• Molecular Formula: C12H18 B N O3
• Molecular Weight: 235.091
• Mol file: 226396-30-1.mol

Synonyms:[4-[2-(Pyrrolidino)ethoxy]phenyl]boronicacid

Chemical Property of 4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYLBORON&

Chemical Property:

• Boiling Point: 421.7±55.0 °C(Predicted)
• PKA: 8?+-.0.16(Predicted)
• PSA: 52.93000
• Density: 1.17±0.1 g/cm3(Predicted)
• LogP: -0.22110
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(4-(2-(Pyrrolidin-1-yl)ethoxy)phenyl)boronicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYLBORON&

There total 2 articles about 4-(2-(1-PYRROLIDINYL)ETHOXY)PHENYLBORON& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + Triisopropyl borate (5419-55-6) → (4-(2-(1-pyrrolidinyl)ethoxy)phenyl)boronic acid (226396-30-1)

Guidance literature:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 1.5h; Cooling with acetone-dry ice;

Triisopropyl borate; In tetrahydrofuran; at 20 ℃; for 15h;

With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine (1081-73-8) + Trimethyl borate (121-43-7,63156-11-6) → (4-(2-(1-pyrrolidinyl)ethoxy)phenyl)boronic acid (226396-30-1)

Guidance literature:

With n-butyllithium; triethylamine; In tetrahydrofuran; methanol;

Reference yield: 79.0%

(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)boronic acid (226396-30-1) + 3-Benzo[1,3]dioxol-5-yl-2-(5-bromo-furan-2-carbonyl)-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one (374927-11-4) → 1,2,3,4-Tetrahydro-3-(3,4-methylenedioxyphenyl)-2-(5-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-furoyl)-9H-pyrrolo[3,4-b]quinolin-9-one

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate;

DOI:10.1021/jm0202573

upstream raw materials:

1-[2-(4-bromophenoxy)ethyl]pyrrolidine

Trimethyl borate

Triisopropyl borate

Downstream raw materials:

C₂₈H₃₂N₆O₂

C₃₀H₃₅N₅O₃

C₃₀H₃₅N₅O₂

C₂₉H₃₂FN₅O₂