3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester
CAS No.:174181-21-6
Molecular Formula:C₄₀H₃₉N₅O₇
Molecular Weight:701.779
Hs Code.:

3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Synonyms:3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Suppliers and Price of 3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

There total 10 articles about 3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119-75-5
2-nitro-N-phenylaniline

: 174181-21-6
3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 110.6 g / toluene / 2 h / 80 °C

2: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

3: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

4: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

5: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1021/jm970265x

Reference yield:

: 174181-40-9
N-(2-nitrophenyl)-N-phenylmalonamic acid methyl ester

: 174181-21-6
3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 43.7 g / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 7 h

2: 2.75 g / NaOEt / ethanol / 1 h / Ambient temperature

3: 1.) NaH / 1.) DMF, RT, 0.5 h, 2.) DMF, RT, 18 h

4: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With hydrogen; sodium ethanolate; sodium hexamethyldisilazane; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm970265x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174181-21-6
3-{1-[(Benzo[1,3]dioxol-5-yl-isopropyl-carbamoyl)-methyl]-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-ylmethyl}-indazole-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 53.4 g / DMAP, Et₃N / acetonitrile / 3 h / Ambient temperature

2: 60 percent / NBS, benzoyl peroxide / CCl₄ / 4.5 h / Heating

3: 1.) NaH, NaN(TMS)2 / 1.) DMF, THF, 0 deg C, 2.) DMF, THF, RT, 2 h

With dmap; N-Bromosuccinimide; Perbenzoic acid; sodium hexamethyldisilazane; sodium hydride; triethylamine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jm970265x