2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE

Base Information

• Chemical Name: 2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE
• CAS No.: 226089-80-1
• Molecular Formula: C16H16 O4 S
• Molecular Weight: 304.367
• Hs Code.: 2932999099
• Mol file: 226089-80-1.mol

Synonyms:2-[2-(BENZENESULFONYLMETHYL)PHENYL]-1,3-DIOXOLANE;2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE;2-[2-(PHENYLSULFONYLMETHYL)PHENYL]-1,3-DIOXOLANE

Chemical Property of 2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 510.548°C at 760 mmHg
• Flash Point: 262.57°C
• PSA: 60.98000
• Density: 1.282g/cm³
• LogP: 3.78670
• Solubility.: slightly sol. in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[2-(Phenylsulfonylmethyl)phenyl]-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE

There total 1 articles about 2-(1,3-DIOXOLAN-2-YL)BENZYL PHENYL SULFONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane (7381-30-8) + ortho-(phenylsulfonylmethyl)benzaldehyde (468751-38-4) → 2-(2-benzenesulfonylmethyl-phenyl)-[1,3]dioxolane (226089-80-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate;

Reference yield:

2-(2-benzenesulfonylmethyl-phenyl)-[1,3]dioxolane (226089-80-1) → o-(phenylethynyl)benzaldehyde (59046-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane

2.1: t-BuOK / tetrahydrofuran; hexane / 20 °C

3.1: 92 percent / aq. p-TsOH / tetrahydrofuran; acetone / 20 h / 40 °C

With n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetone; 1.1: Metallation / 1.2: Addition / 2.1: Elimination / 3.1: Hydrolysis;

Reference yield:

2-(2-benzenesulfonylmethyl-phenyl)-[1,3]dioxolane (226089-80-1) → phosphoric acid 2-benzenesulfonyl-2-(2-[1,3]dioxolan-2-yl-phenyl)-1-[2-(2-phenylethynyl-phenylethynyl)-phenyl]-ethyl ester diethyl ester

Guidance literature:

Multi-step reaction with 7 steps

1.1: BuLi / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane

2.1: t-BuOK / tetrahydrofuran; hexane / 20 °C

3.1: 92 percent / aq. p-TsOH / tetrahydrofuran; acetone / 20 h / 40 °C

4.1: BuLi / tetrahydrofuran; hexane / -78 °C

4.2: tetrahydrofuran; hexane

5.1: t-BuOK / tetrahydrofuran; hexane / 20 °C

6.1: 91 percent / aq. p-TsOH / tetrahydrofuran; acetone / 20 h / 40 °C

7.1: BuLi / tetrahydrofuran; hexane / -78 °C

7.2: tetrahydrofuran; hexane

With n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; acetone; 1.1: Metallation / 1.2: Addition / 2.1: Elimination / 3.1: Hydrolysis / 4.1: Metallation / 4.2: Addition / 5.1: Elimination / 6.1: Hydrolysis / 7.1: Metallation / 7.2: Addition;

upstream raw materials:

2,2,7,7-tetramethyl-3,6-dioxa-2,7-disilaoctane

ortho-(phenylsulfonylmethyl)benzaldehyde

Refernces