2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Base Information

Chemical Name:2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside
CAS No.:1432591-84-8
Molecular Formula:C₅₆H₆₁FO₅SSi₂
Molecular Weight:921.333
Hs Code.:

Synonyms:2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Suppliers and Price of 2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

There total 4 articles about 2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1030825-20-7
3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide

: 1432591-75-7
1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose

: 1432591-84-8
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Guidance literature:: 3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide; With magnesium; In tetrahydrofuran; ethylene dibromide; for 2h; Reflux;

With aluminum (III) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose; With n-butyllithium; In tetrahydrofuran; dibutyl ether; at 20 - 150 ℃; for 5h;

Reference yield: 56.0%

: 1432591-75-7
1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose

: 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene

: 1432591-84-8
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Guidance literature:: 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene; With magnesium; ethylene dibromide; In tetrahydrofuran; Inert atmosphere; Schlenk technique; Reflux;

With aluminum (III) chloride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Schlenk technique; Reflux;

1,6-anhydro-2,4-di-O-tert-butyldiphenylsilyl-β-D-glucopyranose; stereoselective reaction; Further stages;
DOI:10.1021/jo502839e

Reference yield:

: 498-07-7
levoglucosan

: 1432591-84-8
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / tetrahydrofuran / 0 °C

2.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Reflux

2.2: 1 h / 20 °C

2.3: 5 h / 20 - 150 °C

With 1H-imidazole; magnesium; In tetrahydrofuran; ethylene dibromide;