N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

Base Information

Chemical Name:N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester
CAS No.:147529-20-2
Molecular Formula:C₂₆H₂₅N₃O₇S₂
Molecular Weight:555.632
Hs Code.:

Synonyms:N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

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Chemical Property of N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

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Technology Process of N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

There total 6 articles about N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1738-68-7
Gly-OBz

: 147529-19-9
N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycine

: 147529-20-2
N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h;
DOI:10.1021/jo00058a007

Reference yield:

: 85591-54-4
2-tert-butylsulfanyl-1-phenylethanone

: 147529-20-2
N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / ethanol / 48 h / Ambient temperature

2: 1.) pyridine / 1.) CH₂Cl₂, -4 deg C, 5-10 min, 2.) 0 deg C, 1.5 h

3: 1.) Triton B / 1.) 60 deg C, 2.) DMF, 50-60 deg C, 4 h

4: glacial acetic acid / dimethylformamide; H₂O / 2 h / Ambient temperature

5: 87 percent / BOP, diisopropylethylamine (DIEA) / dimethylformamide / 24 h

With pyridine; sodium tetrahydroborate; N-benzyl-trimethylammonium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a007

Reference yield:

: 120886-76-2
2-((2-methyl-2-propyl)thio)-1-phenylethanol

: 147529-20-2
N-<<2-<2-nitrophenyl)dithio>-1-phenylethoxy>carbonyl>glycylglycine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) pyridine / 1.) CH₂Cl₂, -4 deg C, 5-10 min, 2.) 0 deg C, 1.5 h

2: 1.) Triton B / 1.) 60 deg C, 2.) DMF, 50-60 deg C, 4 h

3: glacial acetic acid / dimethylformamide; H₂O / 2 h / Ambient temperature

4: 87 percent / BOP, diisopropylethylamine (DIEA) / dimethylformamide / 24 h

With pyridine; N-benzyl-trimethylammonium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In water; N,N-dimethyl-formamide;
DOI:10.1021/jo00058a007