2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

Base Information

Chemical Name:2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile
CAS No.:1242145-41-0
Molecular Formula:C₁₅H₁₅Cl₂N₃
Molecular Weight:308.21
Hs Code.:

Synonyms:2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

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Chemical Property of 2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

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Technology Process of 2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

There total 2 articles about 2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1242145-42-1
(+/-)-2-chloro-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)benzonitrile

: 1242145-41-0
2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

: 1248593-38-5
2-chloro-4-[(5S)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

Guidance literature:: With Chiralpak AD-H; In methanol; carbon dioxide; Resolution of racemate;
DOI:10.1021/jm100505n

Reference yield:

: 1242145-42-1
(+/-)-2-chloro-4-(3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl)benzonitrile

: 1242145-41-0
2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

Guidance literature:: With chiral SFC Column: AD-H 50 x 250 mm; In methanol; carbon dioxide; Purification / work up; Resolution of racemate;

Reference yield: 85.0%

: 120153-08-4
4-(dihydroxyboranyl)-2-fluorobenzoic acid

: 1242145-41-0
2-chloro-4-[(5R)-3-chloro-5-cyclopentyl-4,5-dihydro-1H-pyrazol-1-yl]benzonitrile

: 1242145-12-5
4-[(5R)-1-(3-chloro-4-cyanophenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl]-2-fluorobenzoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm100505n