Benzofuran,2-methyl-5-(1-methylethyl)-(9CI)

Base Information

• Chemical Name: Benzofuran,2-methyl-5-(1-methylethyl)-(9CI)
• CAS No.: 225933-81-3
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.243
• Mol file: 225933-81-3.mol

Synonyms:Benzofuran,2-methyl-5-(1-methylethyl)-(9CI)

Chemical Property of Benzofuran,2-methyl-5-(1-methylethyl)-(9CI)

Chemical Property:

• PSA: 13.14000
• LogP: 3.86460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzofuran,2-methyl-5-(1-methylethyl)-(9CI)

There total 2 articles about Benzofuran,2-methyl-5-(1-methylethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-isopropylbenzo[b]furan + methyl iodide (74-88-4) → 5-isopropyl-2-methylbenzofuran (225933-81-3)

Guidance literature:

5-isopropylbenzofuran; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere; Schlenk technique;

methyl iodide; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere; Schlenk technique; Cooling;

DOI:10.1002/anie.202103910

Reference yield:

4-Isopropylphenol (99-89-8) → 5-isopropyl-2-methylbenzofuran (225933-81-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere; Schlenk technique

2.1: polyphosphoric acid / toluene / 16 h / 110 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere; Schlenk technique

3.2: 20 °C / Inert atmosphere; Schlenk technique; Cooling

With tert.-butyl lithium; potassium carbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;

DOI:10.1002/anie.202103910

upstream raw materials:

methyl iodide

4-Isopropylphenol

Refernces