Technology Process of Benzofuran, 5-ethyl-2-methyl-
There total 3 articles about Benzofuran, 5-ethyl-2-methyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-ethylbenzofuran;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
Schlenk technique;
methyl iodide;
In
tetrahydrofuran; hexane;
at 20 ℃;
Inert atmosphere;
Schlenk technique;
Cooling;
DOI:10.1002/anie.202103910
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: polyphosphoric acid / toluene / 16 h / 110 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere; Schlenk technique
2.2: 20 °C / Inert atmosphere; Schlenk technique; Cooling
With
n-butyllithium;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1002/anie.202103910
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere; Schlenk technique
2.1: polyphosphoric acid / toluene / 16 h / 110 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere; Schlenk technique
3.2: 20 °C / Inert atmosphere; Schlenk technique; Cooling
With
n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/anie.202103910