(2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride

Base Information

• Chemical Name: (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride
• CAS No.: 1422208-48-7
• Molecular Formula: C₁₈H₂₄N₂O*ClH
• Molecular Weight: 320.862
• Mol file: 1422208-48-7.mol

Synonyms:(2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride

Chemical Property of (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride

There total 3 articles about (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2R,3S,1'R)-3-(t-Boc-amino)-2-hydroxy-4-phenyl-1-<(1-phenylethyl)amino>butane (98737-30-5) → (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride (1422208-48-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.11.118

Reference yield:

(R)-1-phenyl-ethyl-amine (3886-69-9) → (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride (1422208-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 48 h / 65 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.11.118

Reference yield:

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) → (2R,3S)-3-amino-4-phenyl-1-(((R)-1-phenylethyl)amino)butan-2-ol hydrochloride (1422208-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 48 h / 65 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane;

DOI:10.1016/j.bmcl.2012.11.118

upstream raw materials:

(R)-1-phenyl-ethyl-amine

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(2R,3S,1'R)-3-(t-Boc-amino)-2-hydroxy-4-phenyl-1-<(1-phenylethyl)amino>butane

Downstream raw materials:

C₃₀H₃₈N₄O₂

C₃₂H₄₁N₃O₃

C₃₂H₄₁N₃O₃

C₃₁H₃₈N₄O₃